5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors

Details 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2401368

Disclosed are compounds of the formula (I) wherein: R2 is hydrogen, alkyl, or cycloalkyl; R3 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkynyl, lower alkenyl, nitrile, nitro, -COR4, -CO2R4, - CONR4R5, -CONR4OR5, -SO2NR4R5, -SO2NR4R5, -SO2R4, -SO3R4, formula (II), or - NR4R5; Y is N or CR7; R9 is lower alkyl, haloalkyl, or aryl; X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, -NR4R5, -N(O)R4R5, -NR4R5R6W, -SR4, -C(O)R4, -CO2R4, - CONR4R5, -SO2NR4R5, -SO2R4, -SO3R4, P(O)(OR4)(OR5), -T(CH2)mQR4, - C(O)T(CH2)mQR4, or -NR4C(O)T(CH2)mQR5; m is 1 to 6. These compounds are useful for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.

La présente invention concerne des composés représentés par la formule générale (I). Inhibiteurs des kinases cyclino-dépendantes et des kinases à médiation de facteur de croissance, ces composés conviennent particulièrement pour le traitement de troubles à prolifération cellulaire (cancer, athérosclérose et resténose). Dans la formule générale (I), R?2¿ est hydrogène, alkyle, ou cycloalkyle. R?3¿ est hydrogène, alkyle inférieur, alcoxy inférieur, halogène, trifluorométhyle, alkynyle inférieur, alcényle inférieur, nitrile, nitro, -COR?4¿, -CO¿2?R?4¿, -CONR?4¿R?5¿, -CONR?4¿OR?5¿, -SO¿2?NR?4¿R?5¿, -SO¿2?NR?4¿R?5¿, -SO¿2?R?4¿, -SO¿3?R?4¿, groupe représenté par la formule particulière (II), ou -NR?4¿R?5¿. Y est N ou CR?7¿. R?9¿ est alkyle inférieur, haloalkyle, ou aryle. X et Z sont indépendamment hydrogène, halogène, alkyle inférieur, alcoxy inférieur, trifluorométhyle, hydroxy, nitrile, nitro, -NR?4¿R?5¿, -N(O)R?4¿R?5¿, -NR?4¿R?5¿R?6¿W, -SR?4¿, -C(O)R?4¿, -CO¿2?R?4¿, -CONR?4¿R?5¿, -SO¿2?NR?4¿R?5¿, -SO¿2?R?4¿, -SO¿3?R?4¿, P(O)(OR?4¿)(OR?5¿), -T(CH¿2?)¿m?QR?4¿, -C(O)T(CH¿2?)¿m?QR?4¿, ou -NR?4¿C(O)T(CH¿2?)¿m?QR?5¿. Enfin, m vaut 1 à 6.

Affiliated with

Also associated with

Rating

5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1676077