Acidic insulin preparations with improved stability

Details Acidic insulin preparations with improved stability Acidic insulin preparations with improved stability

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2490116

The invention relates to a pharmaceutical formulation comprising a polypeptide selected from a group containing insulin, an insulin metabolite, an insulin analogue, an insulin derivative or combinations thereof and also comprising a surfactant or combinations of several surfactants, optionally a preservative or combinations of several preservatives and optionally an isotonic agent, buffers or additional auxiliary agents or combinations thereof. According to the invention, said pharmaceutical formulation has an acidic pH value.

L'invention concerne une formulation pharmaceutique contenant un polypeptide sélectionné dans un groupe comprenant l'insuline, un métabolite d'insuline, un analogue d'insuline, un dérivé d'insuline ou une combinaison d'entre eux ; un tensio-actif ou des combinaisons de plusieurs tensio-actifs; éventuellement un agent de conservation ou des combinaisons de plusieurs agents de conservation; et éventuellement un agent d'isosotonisation, un tampon ou autres agents auxiliaires ou des combinaisons d'entre eux. La formulation pharmaceutique a une valeur pH située dans la zone acide.

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