C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/64 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2623898
The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising, the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.
Composé peptidique cyclique ou sel correspondant, à effets anti-virus sur le virus de l'hépatite C induits par l'inhibition de la réplication de l'ARN dans un réplicon de ce virus, procédé d'élaboration correspondant qui fait intervenir une réaction de ré-agencement sous des conditions acides légères, et les réactions de modification d'acides aminés ci-après, etc. ; composition pharmaceutique renfermant ce type de composé, et enfin procédé de traitement prophylactique et/ou thérapeutique de l'hépatite C chez un humain ou un animal.
Kamijyo Kazunori
Makino Takuya
Neya Masahiro
Tsujii Eisaku
Yamagishi Yukiko
Astellas Pharma Inc.
Dennison Associates
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