Chromone enteric release formulation

Details Chromone enteric release formulation Chromone enteric release formulation

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61P 37/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2350519

Orally administered sodium cromoglycate has been found to be effective in the treatment of allergic conditions such as asthma, general food allergies, ulcerative colitis, atopic eczema, chronic urticaria and irritable bowel syndrome if it is presented such that the sodium cromoglycate becomes bioavailable within (10) minutes of exposure to intestinal fluid. The sodium cromoglycate may be presented as enteric-coated tablets or individually enteric-coated pellets or microgranules packaged with disintegrant in a ratio of at least 1.2:1 distintegrant: sodium cormoglycate (w:w). Optionally, the patients are first selected to have a total serum IgE level of at least 150 lu/ml.

On a trouvé que l'administration par voie orale de cromoglycate de sodium était efficace dans le traitement d'états allergiques tels que l'asthme, les allergies alimentaires générales, la rectocolite hémorragique, l'eczéma constitutionnel, l'urticaire chronique et les colopathies fonctionnelles, lorsque le cromoglycate de sodium se présente sous une forme biodisponible dans les dix (10) minutes de son exposition au fluide intestinal. Le cromoglycate de sodium peut se présenter sous forme de comprimés entéro-solubles, de pastilles ou microgranules kératinisés individuellement, enrobés d'un agent de désintégration, le rapport pondéral entre l'agent de désintégration et le cromoglycate de sodium étant d'au moins 1,2/1. Le cas échéant, on choisit d'abord des patients présentant un taux sérique total d'IgE d'au moins 150 unités internationales/ml.

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