A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/14 (2006.01) C08J 3/075 (2006.01) C08J 3/24 (2006.01)
Patent
CA 2677532
Methods and compositions for polymerizing materials with the process of making the material causing precipitation of an agent that is subsequently released by the material. In some aspects, controlled delivery of bioactive substances from biodegradable hydro gels is disclosed. In certain embodiments, biodegradable hydrogels formed in situ comprise entrapped precipitated proteins that are ordinarily water soluble. The dissolving and release of the bioactive substance is impeded by the hydrogel structure and takes place at a slow rate, thus controlling the release of said bioactive substance from the hydrogel. Thus a bioactive substance that would normally be rapidly dissolved in a physiological surrounding is, instead, released in a controlled manner. The hydrogel phase also serves to protect the bioactive agent from cells and enzymes present in physiological surroundings.
La présente invention concerne des procédés et des compositions permettant de polymériser des matériaux, lesdits procédés consistant à entraîner la précipitation, par le matériau, d'un agent qui est ensuite libéré par le matériau. Certains aspects décrivent la délivrance contrôlée de substances bio-actives par des hydrogels biodégradables. Dans certains modes de réalisation, les hydrogels biodégradables formés in situ comprennent des protéines précipitées piégées qui sont généralement solubles dans l'eau. La dissolution et la libération de la substance bio-active sont empêchées par la structure de l'hydrogel et prennent beaucoup de temps, ce qui permet de contrôler la libération de ladite substance bio-active par l'hydrogel. Ainsi, une substance bio-active qui normalement serait rapidement dissoute dans un environnement physiologique est, au contraire, libérée de manière contrôlée. La phase de l'hydrogel sert également à protéger l'agent bioactif des cellules et enzymes présents dans les environnements physiologiques.
Incept Llc
Smart & Biggar
LandOfFree
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