Plexin d1 as a target for tumor diagnosis and therapy

Details Plexin d1 as a target for tumor diagnosis and therapy Plexin d1 as a target for tumor diagnosis and therapy

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2615744

The present invention relates to plexin Dl for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin Dl. Diagnosis is suitably effected by detecting the presence of plexin Dl in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin Dl for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin Dl, a nucleic acid encoding plexine Dl or a ligand of plexin Dl for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin Dl. The disorders comprise disorders in which plexin Dl is expressed on tumor cells, tumor blood vessels or activated macrophages.

La présente invention porte sur la plexine D1 utilisée comme protéine pouvant être ciblée dans le traitement ou le diagnostic de troubles qui impliquent l'expression de la plexine D1. Le diagnostic est effectué de manière appropriée par la détection de la présence de plexine D1 dans le corps ou un tissu ou fluide corporel, tandis que le traitement est mis en oeuvre par le ciblage de la plexine D1 pour l'administration d'agents thérapeutiques au niveau du site où le traitement est nécessaire. Cette invention concerne également l'utilisation de molécules qui se lient à la plexine D1, un acide nucléique codant la plexine D1 ou un ligand de la plexine D1 pour la préparation d'une composition thérapeutique pour le traitement ou le diagnostic de troubles qui impliquent l'expression de la plexine D1. Les troubles comprennent des troubles dans lesquels la plexine D1 est exprimée sur des cellules tumorales, des vaisseaux sanguins tumoraux ou des macrophages activés.

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