Artificial antigen presenting cells and methods of use thereof

Details Artificial antigen presenting cells and methods of use thereof Artificial antigen presenting cells and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 35/14 (2006.01) A61K 35/18 (2006.01) A61K 39/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2410510

The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. Methods of use for activation of T lymphocytes are also provided.

La présente invention concerne une cellule présentatrice d'antigène artificiel (AAPC) comportant une cellule eucaryote qui exprime un complexe présentateur d'antigène renfermant une molécule d'antigène d'histocompatibilité (HLA) d'un seul type, au moins une molécule accessoire et au moins un épitope exogène spécifique aux cellules T. Par ailleurs, cette invention concerne des méthodes d'utilisation permettant d'activer les lymphocytes T.

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