Methods and compositions for modulating the interaction...

Details Methods and compositions for modulating the interaction... Methods and compositions for modulating the interaction...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2341782

The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.

Il est apparu que le récepteur orphelin APJ du domaine transmembranaire 7 pouvait agir comme co-récepteur des infections cellulaires dues au virus VIH. L'obtention de lignées de cellules coexprimant le CD4 et l'APJ constitue un outil précieux pour la poursuite des recherches sur les infections par le VIH, et l'élaboration de thérapies anti-VIH.

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