Piperazine derivatives with ccr3 inhibiting activity

Details Piperazine derivatives with ccr3 inhibiting activity Piperazine derivatives with ccr3 inhibiting activity

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/496 (2006.01) A61P 29/00 (2006.01) C07D 211/96 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2574292

Compounds of formula (I) in free or salt form, wherein Ar, R1, R2, R3, X and T have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, particularly an inflammatory or allergic condition such as an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Les composés de formule (I) sous forme libre ou sous forme d'un sel, dans laquelle Ar, R1, R2, R3, X et T ont les significations telles qu'indiquées dans la description, sont utiles pour traiter une affection médiée par le récepteur CCR3, en particulier une affection inflammatoire ou allergique telle qu'une maladie inflammatoire ou un syndrome obstructif. Il est également décrit des compositions pharmaceutiques qui contiennent les composés et des procédés servant à préparer les composés.

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