Oral sustained release pharmaceutical composition of...

Details Oral sustained release pharmaceutical composition of... Oral sustained release pharmaceutical composition of...

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 31/5585 (2006.01)

Patent

CA 2525542

An oral sustained release pharmaceutical composition comprising a plurality of granules having diameters of not more than 1000 gm, each of which comprises a nucleus granule containing beraprost sodium, and a coating agent constituting at least two skin layers including (1) a skin layer containing a relatively water-insoluble macromolecular substance and (2) a skin layer containing a hot- melt low-melting substance, said nucleus granule being coated with said coating agent.

L'invention concerne une composition pharmaceutique buvable à libération prolongée, comportant une pluralité de granulés d'un diamètre non supérieur à 1000 µm, dont chacun renferme un noyau contenant du béraprost sodique, et un agent d'enrobage comprenant au moins deux couches pelliculées, à savoir (1) une couche pelliculée contenant une substance macromoléculaire relativement hydro-insoluble, et (2) une couche pelliculée contenant une substance thermofusible à bas point de fusion, ledit noyau étant enrobé dudit agent d'enrobage.

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