A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/00 (2006.01) C07K 14/485 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2515965
The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.
L'invention concerne la modulation de transactivation de récepteurs tyrosine kinase par transduction de signal dont la médiation est assurée par une protéine G ou un récepteur couplé à une protéine G (GPCR) dans une cellule ou un organisme, qui consiste à inhiber l'activité de la métalloprotéase TACE/ADAM17 et/ou l'activité de l'amphiréguline de ligand du récepteur tyrosine kinase.
Gschwind Andreas
Hart Stefan
Ullrich Axel
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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