Improved particulate compositions for pulmonary delivery

Details Improved particulate compositions for pulmonary delivery Improved particulate compositions for pulmonary delivery

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/12 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2465675

This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (.SIGMA.) is greater than 2, optimally greater than 3.

La présente invention concerne une composition particulaire améliorée permettant d'administrer un médicament dans le système pulmonaire. L'invention concerne une méthode d'identification d'une forme optimale de particules aérodynamiquement légères qui sont hautement dispersibles. Lesdites particules selon l'invention sont obtenues par création de particules de médicament creuses, sphériques (c'est-à-dire, des particules souches) qui s'affaissent au cours du procédé de formation des particules, produisant des particules de médicament ridées, à paroi mince, présentant une densité d'enveloppe très faible. De plus, lesdites particules sont notamment optimales pour des aérosols inhalés lorsque le paramètre d'aire spécifique (.sigma.) est supérieur à 2, de manière optimale supérieur à 3.

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