C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 45/00 (2006.01) C12P 19/34 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2589746
The inventors have discovered an elevated serum response to CBir1 flagellin in Crohn's disease patients. The present invention relates to methods for diagnosis and treatment of Crohn's disease and/or subtypes of Crohn's disease. Diagnosis is accomplished by determining the presence of the anti-CBir1 expression or determining the presence of anti-CBir1 expression and detection of the presence of pANCA. Treatment methods include antigen-directed therapy targeting CBir1 flagellin and manipulating the bacteria in the colon and/or small intestine.
L'invention concerne la découverte selon laquelle les patients atteints de la maladie de Crohn présentent une réponse au sérum élevée à la flagelline CBir1. L'invention concerne des méthodes de diagnostic et de traitement de la maladie de Crohn et/ou de sous-types de celle-ci. Le diagnostic consiste à déterminer la présence de l'expression anti-CBir1 ou la présence de l'expression anti-CBir1 et la détection de la présence de pANCA. Des méthodes de traitement consistent en une thérapie dirigée sur des antigènes ciblant la flagelline CBir1 et une manipulation de la bactérie de le côlon et/ou l'intestin grêle.
Landers Carol J.
Targan Stephan R.
Cedars-Sinai Medical Center
Oyen Wiggs Green & Mutala Llp
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