Ctla-4 antibody and aromatase inhibitor or combination...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2586844

The invention relates to administration of an anti-CTLA4 antibody, particularly human antibodies to human CTLA4, such as those having amino acid sequences of antibodies 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, and 10DI (MDX-010), in combination with an aromatase inhibitor, for treatment of breast cancer. More particularly, the invention relates to administration of an anti-CTLA4 antibody and exemestane for treatment of breast cancer.

L'invention concerne l'administration d'un anticorps d'un anti-CTLA4, en particulier des anticorps humains au CTLA4 humain, par exemple ceux présentant des séquences d'acides aminés des anticorps 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, et 10DI (MDX-010), en combinaison avec un inhibiteur de l'aromatase, pour le traitement du cancer du sein. Plus précisément, l'invention concerne l'administration d'un anticorps anti-CTLA4 et de l'exemestane pour le traitement du cancer du sein.

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