Synthesis of diverse and useful collections of oligonucleotides

Details Synthesis of diverse and useful collections of oligonucleotides Synthesis of diverse and useful collections of oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07H 21/00 (2006.01) C40B 50/00 (2006.01)

Patent

CA 2133554

A new technique for generating mixtures of oligonucleotides in a single automated synthesis is taught. The method can be used to prepare mixed oligonucleotides ideally suited for creation of useful mixtures of oligo- or polypeptides or proteins. Additionally, the technique enables insertion and/or substitution and/or deletion of a nucleotide sequence at one or more sites. For protein mutagenesis, a trinucleotide can be inserted or substituted at codon boundaries. The invented technique makes possible the encoding of all possible single amino acid insertions, or any desired mixture of substitutions and insertions.

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