Amide compounds and use thereof

Details Amide compounds and use thereof Amide compounds and use thereof

C - Chemistry, Metallurgy

07

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C07C 235/60 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/166 (2006.01) A61K 31/215 (2006.01) A61K 31/265 (2006.01) A61K 31/27 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 65/03 (2006.01) C07C 235/84 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 237/44 (2006.01) C07C 251/86 (2006.01) C07C 259/06 (2006.01) C07C 259/18 (2006.01) C07C 271/06 (2006.01) C07C 275/04 (2006.01) C07C 279/04 (2006.01) C07C 279/08 (2006.01) C07C 311/01 (2006.01) C07C 317/02

Patent

CA 2230082

An amide compound of the formula (I) : (see formula I) wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R5 is H, alkyl and the like, m is an integer of 0-6, R6 is an optionally substituted aryl and the like, and R7 is H, an optionally substituted alkyl and the like, a pharmaceutically acceptable acid addition salt thereof and a pharmaceutical containing same as an active ingredient. The amide compounds exhibit superior suppressive effects on cytokines directly or indirectly involved in inflammations, such as IL-8, IL-1, IL-6, TNF-.alpha., GM-CSF and the like, and are useful for the prophylaxis and treatment of rheumatic diseases, arthritis due to gout and the like.

L'invention concerne des composés amide représentés par la formule générale (I), leurs sels d'addition d'acide acceptables sur le plan pharmaceutique, ainsi qu'un médicament contenant ledit composé en tant qu'ingrédient actif. Dans cette formule, R représente amino, etc; A représente alkylène, etc; X représente O, S, etc; M représente arylène, etc; R<1>, R<2>, R<3> et R<4> représentent chacun H, hydroxy, etc; R<5> représente H, alkyle, etc; m est un nombre entier compris entre 0 et 6; R<6> représente aryle, éventuellement substitué, etc; et R<7> représente H, alkyle éventuellement substitué, etc. Ces composés amide ont un excellent effet inhibiteur sur les cytokines (IL-8, IL1, IL-6, TNF- alpha , GM-CSF, etc), agissant directement ou indirectement sur l'inflammation et sont utiles pour la prévention ou le traitement des arthrites induites par des maladies du type rhumatisme, goutte, etc.

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