C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/55 (2006.01) A61K 31/553 (2006.01) A61P 25/00 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2654394
The invention pertains to tricyclic heteroaryl compounds of formula (I) that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDElO. The invention further relates to pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.
L'invention concerne des composés hétéroaryliques tricycliques représentés par la formule (I) servant d'inhibiteurs efficaces de la phosphodiestérase (PDE). L'invention concerne également des composés qui sont des inhibiteurs sélectifs de PDE1O. L'invention concerne également des compositions pharmaceutiques comprenant de tels composés ; et l'utilisation de tels composés dans des procédés pour traiter certains troubles du système nerveux central (CNS) ou autres troubles. L'invention concerne également des procédés pour traiter des troubles neurodégénératifs et psychiatriques, par exemple, la psychose et les troubles comportant une cognition déficiente comme symptôme.
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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