Monovalent antibody fragments useful as therapeutics

Details Monovalent antibody fragments useful as therapeutics Monovalent antibody fragments useful as therapeutics

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2548757

The invention provides methods and compositions comprising a stabilized monovalent antibody fragment, which consists of a single antigen binding arm and Fc region that increases stability while not inducing dimerization, the Fc region comprising a complex of a first and a second Fc polypeptide wherein one only of the Fc polypeptides is an N-terminally truncated heavy chain .

La présente invention se rapporte à des procédés et à des compositions faisant appel à un fragment d'anticorps univalent stabilisé.

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