C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/72 (2006.01) A61K 38/49 (2006.01)
Patent
CA 2718768
The invention relates to tPA mutant devoid of protease activity and uses thereof in compositions and methods for the treatment and prevention of pathologic conditions involving neurological injury or an ischemic disease or condition. More specifically, the invention relates to a Ser481 to Ala mutant of tPA and to compositions and combinations thereof for the treatment of stroke, acute brain injury and neurodegenerative disorders. The invention further provides methods and kits for the treatment of said disorders.
Cette invention concerne un mutant du tPA dépourvu dactivité protéase, ses utilisations dans des compositions et des méthodes de traitement et de prévention daffections pathologiques impliquant des lésions neurologiques ou une maladie ou manifestation ischémique. Linvention concerne plus particulièrement un mutant Ser481 à Ala du tPA, ses compositions et ses associations dans le traitement de laccident vasculaire cérébral, des lésions cérébrales aiguës et des affections neurodégénératives. Linvention concerne par ailleurs des méthodes et des kits de traitement desdites affections.
Higazi Abd
Hijazi Nuha
Hadasit Medical Research Services & Development Ltd.
Shapiro Cohen
LandOfFree
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