C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C12N 15/115 (2010.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07K 7/08 (2006.01) C07K 14/475 (2006.01) C07K 14/51 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2446582
The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
L'invention concerne des réactifs, des composés, des compositions et des procédés relatifs à de nouvelles interactions du domaine extracellulaire de LRP5, HBM (un variant de LRP5), et/ou LRP6 avec Dkk, comprenant Dkk-1. Les divers acides nucléiques, polypeptides, anticorps, procédés de dosage, procédés de diagnostic, et procédés de traitement de l'invention sont afférents à ou ont un impact sur Dkk, LRP5, LRP6, HBM, et la signalisation Wnt. Dkk, LRP5, LRP6, HBM, et Wnt sont impliqués dans la signalisation osseuse et cellulaire adipeuse. Ainsi, l'invention concerne des réactifs et des procédés destinés à moduler les niveaux adipeux et/ou la masse osseuse et est utile dans le traitement et le diagnostic de niveaux adipeux anormaux et de troubles de la masse osseuse, tels que l'ostéoporose.
Allen Kristina
Anisowicz Anthony
Bhat Bheem M.
Damagnez Veronique
Robinson John Allen
Genome Therapeutics Corporation
Oscient Pharmaceuticals Corporation
Torys Llp
Wyeth
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