Drug screening systems and assays

Details Drug screening systems and assays Drug screening systems and assays

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2408749

A method of stimulating non-homologous end-joining (NHEJ) of DNA the method comprising performing NHEJ of DNA in the presence of inositol hexakisphosphate (IP6) or other stimulatory inositol phosphate. An assay of a protein kinase wherein the assay comprises inositol hexakisphosphate (IP6) or other stimulatory inositol phosphate. The invention also provides screening assays for compounds which may modulate NHEJ and which may be therapeutically useful; and screening assays for compounds which may modulate DNA-PK and related protein kinases and which may be therapeutically useful. Methods of modulating NHEJ and protein kinases are also disclosed.

L'invention porte sur un procédé de stimulation de mécanismes d'assemblage non homologue des terminaison d'ADN, ce procédé consistant à réaliser l'assemblage non homologue des terminaisons de l'ADN en présence d'hexakisphosphate inositol (IP¿6?) ou autre phosphate inositol stimulateur. L'invention porte également sur le dosage d'une protéine kinase, ce dosage comprenant hexakisphosphate inositol (IP¿6?) ou autre phosphate inositol stimulateur. L'invention porte encore sur des méthodes de criblage de composés qui peuvent moduler l'assemblage non homologue des terminaisons et être utiles d'un point de vue thérapeutique, ainsi que sur des méthodes de criblage de composés qui peuvent moduler ADN-PK et des protéines kinases apparentées et qui peuvent être utiles d'un point de vue thérapeutique. Des procédés de modulation des mécanismes d'assemblage non homologue des terminaisons, ainsi que des protéines kinases sont également décrits.

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