High molecular weight surface proteins of non-typeable...

Details High molecular weight surface proteins of non-typeable... High molecular weight surface proteins of non-typeable...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/102 (2006.01) A61K 39/385 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/285 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2259133

High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HMW3 and HMW4 have also been cloned, expressed and sequenced.

L'invention concerne des protéines de surface à masse moléculaire élevée d'Haemophilus influenzae de type non déterminable, qui présentent des propriétés immunogènes, et des gènes codant lesdites protéines. L'invention concerne plus spécifiquement des gènes codant pour deux protéines immunodominantes à masse moléculaire élevée, HMW1 et HMW2, qui ont été clonés, exprimés et séquencés, et des gènes codant pour les protéines à masse moléculaire élevée HMW3 et HMW4, qui ont également été clonés, exprimés et séquencés.

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