Anti-proliferative and anti-inflammatory compounds: 5-...

Details Anti-proliferative and anti-inflammatory compounds: 5-... Anti-proliferative and anti-inflammatory compounds: 5-...

C - Chemistry, Metallurgy

07

H

C07H 19/04 (2006.01) A61K 31/70 (2006.01) C07H 15/12 (2006.01) C07H 19/24 (2006.01)

Patent

CA 2104477

2104477 9313117 PCTABS00024 The compounds of this invention are 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom. The saturated nitrogen-containing heterocycle substituent is shown by formula (I) where X is CH2, NH or O; and n ranges from 3-6. These hexose monosaccharides may also be ethereally substituted at least one other position. The compounds exhibit anti-proliferative and anti-inflammatory activity. Methods of preparation, pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.

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