Process for the preparation of...

Details Process for the preparation of... Process for the preparation of...

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01)

Patent

CA 2578767

A process for the preparation of 7-ethyl-10-hydroxy-20(S)- camptothecin comprises the steps of: reducing 7-ethyl- 20(S)-camptothecin to 7-ethyl-1,2,6,7-tetrahydro-20(S)- camptothecin with hydrogen gas catalyzed by a reduction catalyst; and oxidizing the 7-ethyl-1,2,6,7-tetrahydro- 20(S)-camptothecin with an oxidizing agent to produce 7- ethyl-10-hydroxy-20(S)-camptothecin.

Divulgation d'un procédé de préparation de la 7-éthyl-10-hydroxy-20(S)-camptothécine comprenant les étapes suivantes : réduction de la 7-éthyl-20(S)-camptothécine en 7-éthyl-1,2,6,7-tétrahydro-20(S)-camptothécine au moyen d'hydrogène gazeux et d'un catalyseur de réduction; oxydation de la 7-éthyl-1,2,6,7-tétrahydro-20(S)-camptothécine au moyen d'un agent oxydant pour produire la 7-éthyl-10-hydroxy-20(S)-camptothécine.

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