Gene expressed in prostate cancer

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2344620

A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis specific in normal tissues. The 22P4F11 gene is also expressed in human prostate tumors, in some cases at high levels. A full length cDNA encoding 22P4F11 is provided. The 22P4F11 transcript and/or protein may represent a useful diagnostic marker and/or therapeutic target for prostate cancer.

On décrit un nouveau gène à spécificité testiculaire exprimé dans le cancer de la prostate chez l'homme, appelé gène 22P4F11. L'analyse de l'expression d'ARNm du gène 22P4F11 dans une prostate normale, dans les xénogreffes de tumeur de la prostate, et dans une diversité de tissus normaux indique que l'expression de ce gène est spécifique aux testicules dans les tissus normaux. Le gène 22P4F11 est également exprimé dans des tumeurs de la prostate chez l'homme, dans certains cas à des niveaux élevés. Un ADNc entier codant 22P4F11 est décrit. Le transcrit et/ou la protéine du gène 22P4F11 peut représenter un marqueur de diagnostic et/ou une cible thérapeutique utile(s) pour le cancer de la prostate.

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