C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2263165
The present invention provides a polynucleotide which identifies and encodes a human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.
La présente invention concerne un polynucléotide qui identifie et code une protéine de la tumeur induite chez l'homme (HITP). L'invention propose des vecteurs d'expression et des cellules hôtes, obtenus par génie génétique et comprenant la séquence nucléotidique codant la HITP. L'invention propose également de produire et d'utiliser la HITP sensiblement purifiée dans des compositions pharmaceutiques destinées à forcer la différentiation et à arrêter la division des cellules cancéreuses. L'invention décrit des méthodes de diagnostic qui utilisent ledit polynucléotide pour l'hybrider avec les transcrits codant la HITP et les anticorps anti-HITP se liant spécifiquement à cette protéine.
Au-Young Janice
Hawkins Phillip R.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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