Retroviral vector hybrids and the use thereof for gene transfer

Details Retroviral vector hybrids and the use thereof for gene transfer Retroviral vector hybrids and the use thereof for gene transfer

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2199131

The disclosure relates to replication defective retroviral vector hybrids characterized by the fact that they contain: ( a) in the leader region as U5 region and/or tRNA primer binding site, the U5 region and/or tRNA primer binding site of MESV; and (b) as U3 and R regions in 3'-LTR, the U3 and R regions from a Friend murine leukaemia virus (F-MuLV). The proposed hybrids are particularly suitable for effective gene transfer in haematopoietic stem cells.

Hybrides vectoriels rétroviraux à défauts de réplication, caractérisés en ce qu'ils contiennent a) dans la région leader, comme région U5 et/ou comme site de liaison amorce tRNA, la région U5 et/ou le site de liaison amorce tRNA de MESV et, b) comme régions U3 et R en 3'-LTR, les régions U3 et R d'un virus de leucémie murine Friend (F-MuLV). Les hybrides selon l'invention sont particulièrement appropriés pour un transfert efficace de gènes dans des cellules souches hématopoïétiques.

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