C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2530748
The present invention includes methods diagnosising of cancer by analysis of a patient sample, particularly for the presence of a methylated SPARC nucleic acid molecule, and particularly for the diagnosis of pancreatic cancer. The invention also includes therapeutic methods for treating cancers by administering to cancers patients therapeutically effective amounts of demethylating agents.
L'invention concerne des méthodes servant à diagnostiquer le cancer par analyse d'un spécimen prélevé sur le patient, afin de rechercher, en particulier, la présence d'une molécule d'acide nucléique méthylée de SPARC et, en particulier, de diagnostiquer le cancer du pancréas. Elle concerne également des méthodes thérapeutiques servant à traiter certains cancers par administration au patient atteint de ces cancers de quantités efficaces sur le plan thérapeutique d'agents de déméthylation.
Goggins Michael G.
Norihiro Sato
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Johns Hopkins University
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