Stabilized ribozyme analogs

Details Stabilized ribozyme analogs Stabilized ribozyme analogs

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2208427

Disclosed are stabilized ribozyme analogs having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. These ribozyme analogs include modifications at specific loop, catalytic core, and flanking region nucleotides which make them more resistant to nucleases. Also disclosed are methods of preparing and utilizing the ribozyme analogs of the invention, and pharmaceutical formulations and kits containing such ribozyme analogs.

L'invention concerne des analogues de ribozymes stabilisés capables d'effectuer le clivage endonucléolytique d'une séquence de ribonucléotides reliés de 3' à 5'. Ces analogues de ribozymes présentent des modifications au niveau des nucléotides à boucle spécifique, à noyau catalytique et à région adjacente, ce qui accroît leur résistance aux nucléases. Elle concerne également des procédés de préparation et d'utilisation de ces analogues de ribozymes, ainsi que des formulations pharmaceutiques et des kits les contenant.

Affiliated with

Also associated with

Rating

Stabilized ribozyme analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized ribozyme analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized ribozyme analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1685260