Prodrugs of mitotic kinesin inhibitors

Details Prodrugs of mitotic kinesin inhibitors Prodrugs of mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/20 (2006.01)

Patent

CA 2527582

The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

La présente invention concerne des promédicaments d'ester de phosphate de composés dihydropyrrole utiles pour traiter des maladies prolifératives cellulaires, pour traiter des troubles associés à l'activité kinésine KSP, et pour inhiber la kinésine KSP. L'invention concerne également des compositions comprenant ces composés ainsi que des méthodes d'utilisation desdits composés pour traiter le cancer chez des mammifères.

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