Preparation of powder agglomerates

Details Preparation of powder agglomerates Preparation of powder agglomerates

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2282360

The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.

Procédé pour produire un agglomérat formé d'un médicament et d'un liant solide. Ce procédé consiste à produire des particules d'agglomérat individuelles puis à convertir la portion convertible amorphe contenue dans ces particules après l'agglomération, cette dernière étant obtenue par application d'humidité par exemple. L'invention porte sur des agglomérats pouvant être convertis ainsi que sur des agglomérats finis et des systèmes de dosage oral et nasal comprenant ces agglomérats. Ce procédé produit des agglomérats qui sont grossiers mais qui permettent d'obtenir une fraction particulaire d'une finesse acceptable lors du dosage.

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