Streptococcus gordonii strains resistant to fluorodeoxyuridine

C - Chemistry – Metallurgy – 12 – N

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C12N 1/20 (2006.01) C12Q 1/24 (2006.01)

Patent

CA 2370798

The present invention features gram-positive bacteria resistant to 5- fluorodeoxyuridine (FUdR). Such bacteria will preferably be commensal, and will not be resistant to antibiotics. Bacteria according to the present invention may also be transformed with DNA encoding an antigenic protein. Such transformed bacteria may be used to formulate a vaccine, in order to stimulate an immune response to the antigenic protein in a patient. The present invention further provides a method for isolating gram-positive bacteria resistant to FUdR.

La présente invention porte sur des bactéries Gram-positif résistant à 5-fluorodésoxyuridine (FUdR). Ces bactéries peuvent être de préférence commensales, et ne résistent pas aux antibiotiques. Ces bactéries peuvent être également transformées par l'ADN codant une protéine antigénique. Ces bactéries transformées peuvent être utilisées dans la formulation de vaccins afin de stimuler une réponse immune dans la protéine antigénique d'un patient. La présente invention porte en outre sur un procédé d'isolement des bactéries Gram-positif résistant à FUdR.

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