Use of gabapentin in assays to identify gabab receptor...

Details Use of gabapentin in assays to identify gabab receptor... Use of gabapentin in assays to identify gabab receptor...

G - Physics

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G01N 33/50 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2375196

Novel assays utilizing gabapentin to identify agonists, inverse agonists, antagonists, and allosteric modulators of the GABAB receptor, where the functional GABAB receptor results from the co-expression of HG20 and GABABR1a or GABABR1b and formation of heterodimers of HG20 and GABABR1a or GABABR1b subunits, are provided.

L'invention se rapporte à l'utilisation de gabapentine dans de nouvelles analyses destinées à l'identification d'agonistes, d'agonistes inverses, d'antagonistes et d'effecteurs allostériques du récepteur GABA¿B?, dans lesquelles le récepteur fonctionnel de GABA¿B? provient de la co-expression de HG20 et GABA¿B?R1a or GABA¿B?R1b et de la formation d'hétérodimères de sous-unités de HG20 et GABA¿B?R1a ou GABA¿B?R1b.

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