A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4164 (2006.01) A61K 9/00 (2006.01) A61K 31/245 (2006.01) A61K 45/06 (2006.01) A61P 1/04 (2006.01) A61P 17/02 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2496864
A topical composition comprises at least 5-wt % metronidazole or a pharmacologically acceptable derivative thereof in a non-aqueous vehicle. The composition may be used in the treatment of conditions of the colon, rectum, anorectum and perianal region, in particular inflammatory bowel disease and perianal Crohn's disease. The composition also relieves pain and inflammation and promotes healing of the colon, rectum, and anorectum and perianal region following surgical operations. One advantage of the composition is that topical administration of metronidazole results in a primarily local effect and thus side effects observed from systemic administration are avoided.
L'invention se rapporte à une composition topique contenant, dans un excipient non aqueux, au moins 5 % poids de métronidazole ou d'un dérivé pharmaceutiquement acceptable de ce dernier. La composition peut servir au traitement de maladies du colon, du rectum, de l'anorectum et de la région périanale, en particulier de maladies intestinales inflammatoires et de la maladie de Crohn périanale. La composition permet également de soulager la douleur et l'inflammation, et favorise la guérison du colon, du rectum, de l'anorectum et de la région périanale à la suite d'une intervention chirurgicale. L'un des avantages présentés par la composition est que l'administration topique de métronidazole a un effet principalement local, ce qui permet d'éviter les effets indésirables observés lors d'une administration par la voie générale.
S.l.a. Pharma Ag
Sim & Mcburney
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