C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/495 (2006.01) A23J 1/20 (2006.01) C07K 14/65 (2006.01) C07K 16/04 (2006.01) C12N 9/08 (2006.01)
Patent
CA 2454548
The present invention relates to a process for extracting beneficial compounds, in particular growth factors, such as TGF .beta. and IGF-1 from milk. In this process a hydrophobic interaction chromatography step is included. A resin having a butyl group, or a phenyl group as the ligand is used as hydrophobic interaction resin. The resin can be eluted with a salt gradient which, when the ligand is a phenyl group, contains substantially no alcohol, and thus resulting in fractions enriched in the desired growth factors. These fractions can be separated further by means of a hydroxyapatite column.
L'invention concerne un procédé d'extraction de composants bénéficiaires, en particulier de facteurs de croissance, tels que des TGF .beta. et IGF-1 à partir de lait. Dans ce procédé, on trouve également une phase de chromatographie interactive hydrophobe. Une résine possède un groupe butyle ou un groupe phényl comme ligand de résine interactive hydrophobe. Cette résine peut être éluée par un gradient de sel qui, lorsque le ligand est un groupe phényl, ne contient quasiment pas d'alcool et résulte donc en fractions enrichies dans les facteurs de croissance souhaités. On peut séparer ces fractions ultérieurement au moyen d'une colonne hydroxylapatite.
Galama Catharina Maria
Hendriks Andor Wilhelm Joseph
Kivits Marinus Gerardus Cornelis
Campina B.v.
Numico Research B.v.
Ridout & Maybee Llp
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