Recombinant production of saporin-containing proteins

Details Recombinant production of saporin-containing proteins Recombinant production of saporin-containing proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/415 (2006.01) C07K 14/50 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 15/13 (2006.01) C12N 15/16 (2006.01) C12N 15/29 (2006.01) C12N 15/52 (2006.01) C12N 15/70 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2138038

2138038 9325688 PCTABScor01 Methods for the recombinant production of saporin-containing proteins, including cell surface binding protein-saporin fusion proteins, are provided. The resulting fusion proteins are cytotoxic to targeted cells. In preferred embodiments, methods are provided for the production of basic fibroblast factor (bFGF)-saporin fusion proteins by culturing Escherichia coli that has been transformed with a vector containing DNA encoding bFGF linked via a spacer peptide to the amino terminus of a cytotoxic portion of a saporin polypeptide to obtain expression of the DNA, and isolating the resulting FGF-saporin fusion protein. FGF-saporing fusion proteins and saporin proteins containing from about 5 to 12 amino acid N-terminal extensions are also provided.

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