Crystalline pde4d2 catalytic domain complex, and methods for...

Details Crystalline pde4d2 catalytic domain complex, and methods for... Crystalline pde4d2 catalytic domain complex, and methods for...

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) B01D 9/00 (2006.01) C07K 1/00 (2006.01) C12Q 1/44 (2006.01) C30B 29/58 (2006.01) G01N 33/573 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2454572

The presently disclosed subject matter provides a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide. Also provided is a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the presently disclosed subject matter and methods for identifying and designing phosphodiesterase ligands and modulators. Also provided are scalable three-dimensional configurations of points and computer readable storage media containing digitally encoded structural data.

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