Ret ligand (retl) for stimulating neural and renal growth

Details Ret ligand (retl) for stimulating neural and renal growth Ret ligand (retl) for stimulating neural and renal growth

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/566 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2253871

This invention relates to nucleotide sequences which encode a Ret ligant (RetL), as well as to methods of stimulating neural and renal growth by treating cells and mammalian subjects with RetL DNA or protein. The invention provides a purified and isolated DNA molecule coding for a RetL, having the nucleotide sequence of any RetL, but specifically including rat retL 1 cDNA (SEQ ID NO.1), partial human RetL1 cDNA (SEQ ID N0:8), full length human retL 1 cDNA (SEQ ID NO:10), human retL2 cDNA (SEQ ID NO:12), murine retL3 cDNA (SEQ ID NO:16), partial human retL3 cDNA (SEQ ID NO:18) or human retL3 cDNA (SEQ ID NO:20). The invention further provides a RetL protein, with an amino acid sequence comprising that of rat RetL 1 (SEQ ID NO:2), partial human RetL1 (SEQ ID NO:9), full length human RetL (SEQ ID NO:11), human RetL2 (SEQ ID NO:13), murine RetL3 (SEQ ID NO:17), partial human RetL3 (SEQ ID NO:19) or human RetL3 (SEQ ID NO:21).

Cette invention concerne des séquences de nucléotides codant un ligand Ret (RetL), ainsi que des procédés de stimulation de la croissance neurale et rénale qui consistent à traiter des cellules et des mammifères à l'aide d'ADN ou de protéine de RetL. Cette invention permet d'obtenir une molécule d'ADN purifiée et isolée, laquelle code pour un RetL et possède la séquence de nucléotide d'un RetL quel qu'il soit. D'une manière plus spécifique, cette molécule comprend un ADNc de retL1 du rat (N DEG ID SEQ 1), un ADNc de retL1 humain partiel (N DEG ID SEQ 8), un ADNc de retL1 humain complet (N DEG ID SEQ 10), un ADNc de retL2 humain (N DEG ID SEQ 12), un ADNc de retL3 murin (N DEG ID SEQ 16), un ADNc de retL3 humain partiel (N DEG ID SEQ 18) ou, encore, un ADNc de retL3 humain (N DEG ID SEQ 20). Cette invention concerne également une protéine de RetL, ainsi qu'une séquence d'acide aminé comprenant celle d'un RetL1 du rat (N DEG ID SEQ 2), d'un RetL1 humain partiel (N DEG ID SEQ 9), d'un RetL1 humain complet (N DEG ID SEQ 11), d'un RetL2 humain (N DEG ID SEQ 13), d'un RetL3 murin (N DEG ID SEQ 17), d'un RetL3 humain partiel (N DEG ID SEQ 19) ou, encore, d'un RetL3 humain (N DEG ID SEQ 21).

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