Process for preparing...

Details Process for preparing... Process for preparing...

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) C07D 263/44 (2006.01)

Patent

CA 2357953

A process for preparing N-[1-(S)-ethoxycarbonyl-3- phenylpropyl]-L-alanine N-carboxyanhydride of the following formula (I), (see formula I) is to react N-[1-(S)-ethyoxy carbonyl-3-phenylpropyl]-L-alanine with XCOOR, wherein X is halogen atom, R is C1-C6 alkyl, to obtain a N- alkoxycarbonyl compound, then reacting with an acyl group activation reagent, finally contact with water. The compound of formula (I) is a key intermediate of ACE inhibitors.

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