Deuterated catecholamine derivatives and medicaments...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/26 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2642593

The present invention concerns deuterated catecholamine derivatives as well as pharmaceuticals containing these compounds. In addition, the invention concerns the use of deuterated catecholamine derivatives as well as physiologically acceptable salts thereof, and also pharmaceutical compositions, which contain these compounds, also in combination with enzyme inhibitors, for the treatment of dopamine deficiency diseases or diseases which are based on disrupted tyrosine transport or disrupted tyrosine decarboxylase, as well as other disorders.

La présente invention concerne des dérivés de catécholamine deutériés ainsi que des compositions pharmaceutiques contenant ces composés. Par ailleurs, l'invention concerne l'utilisation de dérivés de catécholamine deutériés ainsi que des sels physiologiquement acceptables dérivés, et aussi des compositions pharmaceutiques qui contiennent ces composés, aussi en combinaison avec des inhibiteurs d'enzymes, pour le traitement de maladies de déficience en dopamine, ou de maladies basées sur le transport interrompu de la tyrosine ou d'une décarboxylase interrompue de tyrosine, ainsi que d'autres affections.

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