G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) A61K 49/00 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A01N 61/00 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2595403
The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase- mediated interaction of T-bet with GAT A-3, as well as methods of use therefore.
La présente invention est fondée au moins en partie sur l'identification d'un mécanisme par lequel T-bet module directement la production de cytokines Th2. L'invention concerne des procédés permettant d'identifier les agents modulant l'interaction, activée par la kinase Tec, de T-bet avec GAT A-3, ainsi que des méthodes d'utilisation de ceux-ci.
Glimcher Laurie H.
Hwang Eun Sook
Szabo Susanne J.
Borden Ladner Gervais Llp
President And Fellows Of Harvard College
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