A novel inhibitor of programmed cell death

Details A novel inhibitor of programmed cell death A novel inhibitor of programmed cell death

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2363621

The present invention provides a human apoptosis regulator protein (Aven) and polynucleotides which identify and encode Aven. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Aven, and a method for producing Aven. The invention also provides for agonists, antibodies, or antagonists specifically binding Aven, and their use, in the prevention and treatment of diseases associated with expression of Aven. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Avent for the treatment of diseases associated with the expression of Aven. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Aven.

La présente invention concerne une protéine régulatrice d'apoptose (Aven) et des polynucléotides qui identifient et codent la protéine Aven. L'invention concerne aussi des vecteurs d'expression mis au point par génie génétique ainsi que des cellules hôtes contenant les séquences d'acides nucléiques codant la protéine Aven, et un procédé de production de protéine Aven. L'invention concerne aussi des agonistes, des anticorps, ou des antagonistes se liant spécifiquement à la protéine Aven, et leurs utilisations dans la prévention et le traitement de maladies associées avec l'expression de cette protéine. L'invention concerne, en outre, l'utilisation de molécules antisens à des polynucléotides codant pour la protéine Aven pour le traitement de maladies associées avec son expression, ainsi que des tests de diagnostiques qui utilisent le polynucléotide, ou des fragments de son complément, et des anticorps se liant spécifiquement à la protéine Aven.

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