An over-expressing homologous antigen vaccine and a method...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/04 (2006.01) A61K 39/106 (2006.01) C07K 14/23 (2006.01) C12N 15/00 (2006.01) C12N 15/74 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2317806

This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering form disease caused by a pathogenic micro-organism. The vaccine is an attenuated or avirulent pathogenic micro-organism that over-expresses at least one homologous antigen encoded by at least one gene derived form the pathogenic micro-organism, and may also express a heterologous antigen.

Cette invention concerne un vaccin contenant un alloantigène surexprimé, un procédé de préparation de ce vaccin et l'utilisation de ce dernier dans la prophylaxie ou le traitement de vertébrés qui présentent le risque de souffrir d'une maladie provoquée par un micro-organisme pathogène ou qui souffrent déjà d'une telle maladie. Le vaccin est un micro-organisme pathogène atténué ou avirulent qui surexprime au moins un alloantigène codé par au moins un gène provenant du micro-organisme pathogène, et qui peut également exprimer un antigène hétérologue.

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