A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 1/00 (2006.01) A01N 1/02 (2006.01) A61M 1/16 (2006.01) A61M 1/34 (2006.01) C02F 3/00 (2006.01) C02F 3/02 (2006.01)
Patent
CA 2379937
A device for performing a biological modification of a fluid, the device includes (a) a chamber having an inlet for intake of the fluid and an outlet for outflow of the fluid; and (b) a collection of micro-organ cultures of at least one organ for performing the biological modification of the fluid, each individual mirco-organ culture of the collection including cells and having dimensions, such that cells positioned deepest within the individual micro- organ culture are at least about 100 micrometers and not more than about 225 micrometers away from a nearest surface of the individual micro-organ culture, thereby in vivo organ architecture (organ structure) of organ units (e.g., acinus of liver) is maintained within each individual micro-organ culture, the collection of micro-organ cultures being located within the chamber and the collection of micro-organ cultures being in contact with at least a portion of the fluid flowing through the chamber.
Cette invention se rapporte à un dispositif permettant de réaliser une modification biologique d'un fluide et comprenant à cet effet: (a) une chambre ayant une entrée pour l'admission du fluide et une sortie pour l'évacuation du fluide; et (b) une collection de cultures d'au moins un micro-organe, en vue de réaliser la modification biologique du fluide, chaque culture de micro-organe individuelle de cette collection contenant des cellules et ayant des dimensions telles que les cellules placées au niveau le plus profond à l'intérieur de la culture de micro-organe individuelle sont distantes d'au moins 100 micromètres environ et d'environ 225 micromètres au maximum de la surface la plus proche de la culture de micro-organe individuelle. Ainsi, une architecture d'organein vivo (structure d'organe) d'unités d'organe (par exemple l'acinus du foie) est maintenue à l'intérieur de chacune des cultures de micro-organe individuelle, la collection de ces cultures de micro-organe étant placée à l'intérieur de ladite chambre, en contact avec au moins une partie du fluide s'écoulant à travers ladite chambre.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Yissum Research Development Company Of The Hebrew University Of
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