Enhanced protein thermostability and temperature resistance

Details Enhanced protein thermostability and temperature resistance Enhanced protein thermostability and temperature resistance

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/02 (2006.01) C07K 14/195 (2006.01) C12N 9/96 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2409347

Small heat shock proteins, e.g., Pyrococcus fuiosus (Pfu-sHSP), confer thermotolerance on cellular cultures and on proteins in cellular extracts during prolonged incubation at elevated temperature, demonstrating the ability to protect cellular proteins and maintain cellular viability under heat stress conditions. Such heat shock proteins are effective to combat enzymatic aggregation and intracellular precipitation during heat stress, and thereby enable enhancement of the utility and stability of enzymes in various applications, e. g., Taq polymerase in PCR applications, digestive enzymes in microbial degradative applications, etc.

Les petites protéines de stress, par exemple Pyrococcus furiosus (Pfu-sHSP), confèrent une certaine thermotolérance aux cultures cellulaires et aux protéines présentes dans des extraits cellulaires lors d'une incubation prolongée à température élevée, ce qui démontre leur capacité à protéger les protéines cellulaires et à maintenir la viabilité des cellules dans des conditions de stress thermique. Lesdites protéines de stress combattent efficacement l'agrégation enzymatique et la précipitation intracellulaire pendant le stress thermique, améliorant ainsi l'utilité et la stabilité des enzymes dans le cadre de diverses applications, notamment la polymérase Taq dans les applications d'amplification du type PCR, les enzymes digestives dans les applications de dégradation microbienne, etc..

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