Metabolism-modulating agents and uses therefor

Details Metabolism-modulating agents and uses therefor Metabolism-modulating agents and uses therefor

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2577169

The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5' monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.

L'invention concerne des procédés et des agents de modulation de l~adipogénèse. Plus particulièrement, la présente invention concerne des molécules modulant le niveau d~activité fonctionnelle de l~inosine 5'-monophosphate déshydrogénase (IMPDH) ainsi qu~à leur emploi dans la modulation de l~accumulation des lipides dans les adipocytes et/ou la différenciation entre préadipocytes et les adipocytes pour traiter ou prévenir les troubles liés à l~adiposité, notamment, mais pas uniquement, l~obésité, les lipomes, la lipomatose, la cachexie cancéreuse, la lipodystrophie ou la perte de tissus adipeux lors de traumatismes ou de conditions atrophiques.

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