Multiplex analysis using membrane-bound sensitizers

Details Multiplex analysis using membrane-bound sensitizers Multiplex analysis using membrane-bound sensitizers

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12M 1/00 (2006.01) G01N 27/00 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2475516

The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated analytes, after which the molecular tags are released upon activation of cleavage moieties, or sensitizers, anchored in the same membrane as the membrane-associated analytes. The released molecular tags are then identified by their distinct separation and detection characteristics.

L'invention concerne des procédés et des compositions permettant de déterminer la présence, l'absence, et/ou les quantités d'analytes associés à une ou plusieurs membranes dans un échantillon. Selon l'invention, des composés de liaison dérivés avec des étiquettes moléculaires libérables se fixent spécifiquement à des analytes sélectionnés associés à une ou plusieurs membranes, puis les étiquettes moléculaires sont libérées lors de l'activation de fractions de clivage ou de sensibilisateurs ancrés dans la même membrane que lesdits analytes. Les étiquettes moléculaires libérées sont ensuite identifiées au moyen de leurs caractéristiques de séparation et de détection distinctes.

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