C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) C07C 251/08 (2006.01) C07D 257/04 (2006.01) C07D 403/10 (2006.01)
Patent
CA 2595962
The invention relates to a novel method for the production of losartan, an imidazol derivative with the chemical name 2-n-butyl-4-chloro-5-hydroxymethyl- 1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-]methyl}imidazol and the pharmacologically active salts thereof. The invention also relates to novel intermediate products which are suitable for the production of losartan, and to novel methods for the production of intermediate compounds which are suitable for the production of losartan. One aspect of the invention is a method for the production of a compound of general formula (I), which can arise as an intermediate step in the inventive representation of losartan.
L'invention concerne un nouveau procédé pour produire du Losartane, un dérivé d'imidazole, nommé 2-n-Butyl-4-chloro-5-hydroxyméthyle-1-{[2'-(1H-tétrazol-5-yl)biphényl-4-]méthyle}imidazole ainsi que leurs sels pharmaceutiquement actifs. L'invention concerne également de nouveaux produits intermédiaires, qui conviennent à la production de Losartane, ainsi que de nouveaux procédés permettant de produire des composés intermédiaires, qui conviennent à la production du Losartane. L'invention concerne, en outre, un procédé destiné à produire un composé de formule (I), lequel peut apparaître comme une étape intermédiaire lors de l'isolement du Losartane.
Li Yi
Li Yonggang
Li Yulin
Wang Yaping
Zheng Guojun
Osler Hoskin & Harcourt Llp
Ratiopharm Gmbh
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