C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/04 (2006.01) A61P 1/04 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2726917
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.
L'invention concerne de nouveaux peptides d'agoniste de guanylate cyclase-C et leur utilisation dans le traitement de maladies humaines telles que les troubles gastro-intestinaux, l'inflammation ou le cancer (par ex., un cancer gastro-intestinal). Les peptides peuvent être administrés soit seuls, soit en combinaison avec un inhibiteur de phosphodiestérase dépendant de GMPc. Le trouble gastro-intestinal peut être classifié comme syndrome du côlon irritable, constipation, ou acidité excessive, etc. La maladie gastro-intestinale peut être classifiée comme affection abdominale inflammatoire ou une autre affection gastro-intestinale, telle que la maladie de Crohn, la colite ulcérative ou le cancer.
Jacob Gray S.
Shailubhai Kunwar
Ridout & Maybee Llp
Synergy Pharmaceuticals Inc.
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