C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/18 (2006.01) C07C 43/196 (2006.01) C07C 49/84 (2006.01) C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 473/34 (2006.01) C07F 9/547 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2172534
Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
L'invention concerne des analogues de nucléosides carbocycliques fusionnés à 4',6'-cyclopropane, de conformation verrouillée. Les composés sont préparés en condensant un alcool allylique carbocyclique fusionné à cyclopropane avec des bases à substitution purine ou pyrimidine. Les produits de condensation sont ensuite modifiés afin d'obtenir adénosine, guanosine, cytidine, thymidine et des analogues de nucléoside uracil. Les composés sont utiles en thérapie comme antimétabolites, ou dans la préparation d'agents antimétaboliques.
Barchi Joseph J. Jr.
Marquez Victor E.
Nicklaus Marc C.
Rodriguez Juan B.
Siddiqui Maqbool A.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
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